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fear conditioning arena  (Med Associates Inc)


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    Med Associates Inc fear conditioning arena
    D-TTM020 restores contextual fear memory in Mecp2 het mice. ( A <t>)</t> <t>Fear-conditioning</t> paradigm, ( B ) contextual fear memory. D-TTM020-treated hets rescued conditioned fear memory to baseline levels. ( C ) Fear extinction test (Cue response). D-TTM020 improved contextual fear memory and cue response in Mecp2 hets versus saline and free TTM020. *** p < 0.001, ** p < 0.01, * p < 0.05 in comparison to the saline-treated hets. Data is represented as mean ± SD. n = 9–13/group.
    Fear Conditioning Arena, supplied by Med Associates Inc, used in various techniques. Bioz Stars score: 97/100, based on 76 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/fear+conditioning+arena/Contextual+Conditioning+Protocol+Package/pmc12897355-91-12-19
    Average 97 stars, based on 76 article reviews
    fear conditioning arena - by Bioz Stars, 2026-09
    97/100 stars

    Images

    1) Product Images from "Dendrimer-Conjugated Glutamine Antagonist, D-TTM020, Ameliorates Brain Immune Dysregulation and Improves Neurobehavioral Deficits in the Mecp2- Deficient Mouse Model"

    Article Title: Dendrimer-Conjugated Glutamine Antagonist, D-TTM020, Ameliorates Brain Immune Dysregulation and Improves Neurobehavioral Deficits in the Mecp2- Deficient Mouse Model

    Journal: Cells

    doi: 10.3390/cells15030272

    D-TTM020 restores contextual fear memory in Mecp2 het mice. ( A ) Fear-conditioning paradigm, ( B ) contextual fear memory. D-TTM020-treated hets rescued conditioned fear memory to baseline levels. ( C ) Fear extinction test (Cue response). D-TTM020 improved contextual fear memory and cue response in Mecp2 hets versus saline and free TTM020. *** p < 0.001, ** p < 0.01, * p < 0.05 in comparison to the saline-treated hets. Data is represented as mean ± SD. n = 9–13/group.
    Figure Legend Snippet: D-TTM020 restores contextual fear memory in Mecp2 het mice. ( A ) Fear-conditioning paradigm, ( B ) contextual fear memory. D-TTM020-treated hets rescued conditioned fear memory to baseline levels. ( C ) Fear extinction test (Cue response). D-TTM020 improved contextual fear memory and cue response in Mecp2 hets versus saline and free TTM020. *** p < 0.001, ** p < 0.01, * p < 0.05 in comparison to the saline-treated hets. Data is represented as mean ± SD. n = 9–13/group.

    Techniques Used: Saline, Comparison

    Related Articles

    Saline:

    Article Title: Dendrimer-Conjugated Glutamine Antagonist, D-TTM020, Ameliorates Brain Immune Dysregulation and Improves Neurobehavioral Deficits in the Mecp2- Deficient Mouse Model
    Article Snippet: Open field: In the 8th week, mouse activity was assessed in an open-field enclosure (38 × 26.5 cm) for 10 min. ANY-maze software (version 7.3, Stoelting Co., Wood Dale, IL, USA) quantified distance traveled and mean speed in the enclosure [ ].Open field: In the 8th week, mouse activity was assessed in an open-field enclosure (38 × 26.5 cm) for 10 min. ANY-maze software (version 7.3, Stoelting Co., Wood Dale, IL, USA) quantified distance traveled and mean speed in the enclosure [ ].. Contextual fear conditioning: On day 1, the mice were introduced to a fear-conditioning arena (10.75′′ × 9.97′′ × 11.25′′; Med Associates, St. Albans, VT, USA) and allowed to habituate for two minutes.. Animal were habituated for 2 min and then exposed to three tone–shock pairings (2 min apart) for 30 s each, with a 2 s shock (0.7 mV) co-terminating with the tone.Animal were habituated for 2 min and then exposed to three tone–shock pairings (2 min apart) for 30 s each, with a 2 s shock (0.7 mV) co-terminating with the tone.

    Comparison:

    Article Title: Dendrimer-Conjugated Glutamine Antagonist, D-TTM020, Ameliorates Brain Immune Dysregulation and Improves Neurobehavioral Deficits in the Mecp2- Deficient Mouse Model
    Article Snippet: Open field: In the 8th week, mouse activity was assessed in an open-field enclosure (38 × 26.5 cm) for 10 min. ANY-maze software (version 7.3, Stoelting Co., Wood Dale, IL, USA) quantified distance traveled and mean speed in the enclosure [ ].Open field: In the 8th week, mouse activity was assessed in an open-field enclosure (38 × 26.5 cm) for 10 min. ANY-maze software (version 7.3, Stoelting Co., Wood Dale, IL, USA) quantified distance traveled and mean speed in the enclosure [ ].. Contextual fear conditioning: On day 1, the mice were introduced to a fear-conditioning arena (10.75′′ × 9.97′′ × 11.25′′; Med Associates, St. Albans, VT, USA) and allowed to habituate for two minutes.. Animal were habituated for 2 min and then exposed to three tone–shock pairings (2 min apart) for 30 s each, with a 2 s shock (0.7 mV) co-terminating with the tone.Animal were habituated for 2 min and then exposed to three tone–shock pairings (2 min apart) for 30 s each, with a 2 s shock (0.7 mV) co-terminating with the tone.



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    D-TTM020 restores contextual fear memory in Mecp2 het mice. ( A <t>)</t> <t>Fear-conditioning</t> paradigm, ( B ) contextual fear memory. D-TTM020-treated hets rescued conditioned fear memory to baseline levels. ( C ) Fear extinction test (Cue response). D-TTM020 improved contextual fear memory and cue response in Mecp2 hets versus saline and free TTM020. *** p < 0.001, ** p < 0.01, * p < 0.05 in comparison to the saline-treated hets. Data is represented as mean ± SD. n = 9–13/group.
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    D-TTM020 restores contextual fear memory in Mecp2 het mice. ( A <t>)</t> <t>Fear-conditioning</t> paradigm, ( B ) contextual fear memory. D-TTM020-treated hets rescued conditioned fear memory to baseline levels. ( C ) Fear extinction test (Cue response). D-TTM020 improved contextual fear memory and cue response in Mecp2 hets versus saline and free TTM020. *** p < 0.001, ** p < 0.01, * p < 0.05 in comparison to the saline-treated hets. Data is represented as mean ± SD. n = 9–13/group.
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    D-TTM020 restores contextual fear memory in Mecp2 het mice. ( A <t>)</t> <t>Fear-conditioning</t> paradigm, ( B ) contextual fear memory. D-TTM020-treated hets rescued conditioned fear memory to baseline levels. ( C ) Fear extinction test (Cue response). D-TTM020 improved contextual fear memory and cue response in Mecp2 hets versus saline and free TTM020. *** p < 0.001, ** p < 0.01, * p < 0.05 in comparison to the saline-treated hets. Data is represented as mean ± SD. n = 9–13/group.
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    UGO Basile S.R.L fear conditioning arena
    Activation of GABA neurons in the dorsal dentate gyrus reduces fear expression. (A) Upper image: schematic illustration of the injection site of rAAV-hSyn-DIO-hM3DGq-mCherry (Gq) or rAAV-hSyn-DIO-hM4DGi-mCherry (Gi) in the dorsal dentate gyrus (DG) of VGAT-cre mice. Lower image: immunohistochemical distribution of mCherry in the dorsal DG (arrows point towards individual immuno-positive GABA neurons). (B) Schematic fear <t>conditioning</t> protocol. On day 1 (D1), five pairings of a CS (20 s) followed by a 5 s trace and a 0.5 mA footshock were delivered with a variable inter-trial interval of 40–60 s. On day 2 (D2), mice were placed into the acquisition context for 25 min. On day 3 (D3), mice were injected with 1 mg/kg clozapine-N-oxide (CNO) 30 min before fear recall testing, consisting of 5CS presentations in a different context. (C) Equal fear acquisition for all groups, (D) no change in contextual fear, (E) during testing of CS-induced fear recall, Gq group showed a lower percentage of freezing than Gi and saline during 5 CS as demonstrated by two-way ANOVA for repeated measurements and Tukey’s post hoc test. (F) A similar reduction of the percentage of freezing was seen during the trace period. (G) Saline, Gq, and Gi injected mice showed a higher percentage of freezing during the trace period compared to the CS, suggesting intact stimulus contingency. Data are presented as means ± SEM, * P < 0.05. Saline: n = 11, Gi: n = 6, Gq: n = 14. Abbreviation: CS, conditioned stimulus.
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    Image Search Results


    D-TTM020 restores contextual fear memory in Mecp2 het mice. ( A ) Fear-conditioning paradigm, ( B ) contextual fear memory. D-TTM020-treated hets rescued conditioned fear memory to baseline levels. ( C ) Fear extinction test (Cue response). D-TTM020 improved contextual fear memory and cue response in Mecp2 hets versus saline and free TTM020. *** p < 0.001, ** p < 0.01, * p < 0.05 in comparison to the saline-treated hets. Data is represented as mean ± SD. n = 9–13/group.

    Journal: Cells

    Article Title: Dendrimer-Conjugated Glutamine Antagonist, D-TTM020, Ameliorates Brain Immune Dysregulation and Improves Neurobehavioral Deficits in the Mecp2- Deficient Mouse Model

    doi: 10.3390/cells15030272

    Figure Lengend Snippet: D-TTM020 restores contextual fear memory in Mecp2 het mice. ( A ) Fear-conditioning paradigm, ( B ) contextual fear memory. D-TTM020-treated hets rescued conditioned fear memory to baseline levels. ( C ) Fear extinction test (Cue response). D-TTM020 improved contextual fear memory and cue response in Mecp2 hets versus saline and free TTM020. *** p < 0.001, ** p < 0.01, * p < 0.05 in comparison to the saline-treated hets. Data is represented as mean ± SD. n = 9–13/group.

    Article Snippet: Contextual fear conditioning: On day 1, the mice were introduced to a fear-conditioning arena (10.75′′ × 9.97′′ × 11.25′′; Med Associates, St. Albans, VT, USA) and allowed to habituate for two minutes.

    Techniques: Saline, Comparison

    Activation of GABA neurons in the dorsal dentate gyrus reduces fear expression. (A) Upper image: schematic illustration of the injection site of rAAV-hSyn-DIO-hM3DGq-mCherry (Gq) or rAAV-hSyn-DIO-hM4DGi-mCherry (Gi) in the dorsal dentate gyrus (DG) of VGAT-cre mice. Lower image: immunohistochemical distribution of mCherry in the dorsal DG (arrows point towards individual immuno-positive GABA neurons). (B) Schematic fear conditioning protocol. On day 1 (D1), five pairings of a CS (20 s) followed by a 5 s trace and a 0.5 mA footshock were delivered with a variable inter-trial interval of 40–60 s. On day 2 (D2), mice were placed into the acquisition context for 25 min. On day 3 (D3), mice were injected with 1 mg/kg clozapine-N-oxide (CNO) 30 min before fear recall testing, consisting of 5CS presentations in a different context. (C) Equal fear acquisition for all groups, (D) no change in contextual fear, (E) during testing of CS-induced fear recall, Gq group showed a lower percentage of freezing than Gi and saline during 5 CS as demonstrated by two-way ANOVA for repeated measurements and Tukey’s post hoc test. (F) A similar reduction of the percentage of freezing was seen during the trace period. (G) Saline, Gq, and Gi injected mice showed a higher percentage of freezing during the trace period compared to the CS, suggesting intact stimulus contingency. Data are presented as means ± SEM, * P < 0.05. Saline: n = 11, Gi: n = 6, Gq: n = 14. Abbreviation: CS, conditioned stimulus.

    Journal: Frontiers in Synaptic Neuroscience

    Article Title: NPY Released From GABA Neurons of the Dentate Gyrus Specially Reduces Contextual Fear Without Affecting Cued or Trace Fear

    doi: 10.3389/fnsyn.2021.635726

    Figure Lengend Snippet: Activation of GABA neurons in the dorsal dentate gyrus reduces fear expression. (A) Upper image: schematic illustration of the injection site of rAAV-hSyn-DIO-hM3DGq-mCherry (Gq) or rAAV-hSyn-DIO-hM4DGi-mCherry (Gi) in the dorsal dentate gyrus (DG) of VGAT-cre mice. Lower image: immunohistochemical distribution of mCherry in the dorsal DG (arrows point towards individual immuno-positive GABA neurons). (B) Schematic fear conditioning protocol. On day 1 (D1), five pairings of a CS (20 s) followed by a 5 s trace and a 0.5 mA footshock were delivered with a variable inter-trial interval of 40–60 s. On day 2 (D2), mice were placed into the acquisition context for 25 min. On day 3 (D3), mice were injected with 1 mg/kg clozapine-N-oxide (CNO) 30 min before fear recall testing, consisting of 5CS presentations in a different context. (C) Equal fear acquisition for all groups, (D) no change in contextual fear, (E) during testing of CS-induced fear recall, Gq group showed a lower percentage of freezing than Gi and saline during 5 CS as demonstrated by two-way ANOVA for repeated measurements and Tukey’s post hoc test. (F) A similar reduction of the percentage of freezing was seen during the trace period. (G) Saline, Gq, and Gi injected mice showed a higher percentage of freezing during the trace period compared to the CS, suggesting intact stimulus contingency. Data are presented as means ± SEM, * P < 0.05. Saline: n = 11, Gi: n = 6, Gq: n = 14. Abbreviation: CS, conditioned stimulus.

    Article Snippet: In brief, trace fear acquisition was performed in context A, consisting of a fear conditioning arena made of a transparent acrylic chamber with a metal grid floor (Ugo Basile, Italy).

    Techniques: Activation Assay, Expressing, Injection, Immunohistochemical staining, Saline